They have been experimented only on cells lines and in animal models (Gonzalez et al., 2006; Frankenberry et al., 2004; Lee et al., 2014; Sharma et al., 2006; Saxena et al., 2007; Cheng et al. 2011; Gonzalez et al., 2009).Targeted therapeutic strategies combined with anti-leptin compounds may have the potential to increase and improve the efficacy of cancer therapy protocols. The gene discussed is LEP; the disease is cancer.