Although a largebody of experimental results points towards a positiveassociation of CYP1A1 genetic polymorphisms and canceroccurrence, further investigation is required for such findingsto be extrapolated successfully to human populations.The present study aimed to find any association between CYP1A1 T6235C,C4887Aand A4889G polymorphisms with the risk of oral cancer and pre cancer. This evidence concerns the gene CYP1A1 and lip and oral cavity carcinoma.