However after adjusting the odds ratio for age and sex the GG genotype for CYP1A1 (A4889G) polymorphism found to be associated with significantly reduce risk for development of oral cancer and oral pre cancer (odd ratio 0.24, 95% CI 0.06-0.91 , p value 0.025). Here, CYP1A1 is linked to lip and oral cavity carcinoma.