In the present study, we observed that: (1) lncRNA ITSN1‐2 was highly expressed in sepsis patients compared to healthy controls, and it presented a good diagnostic value for sepsis; (2) lncRNA ITSN1‐2 expression was positively correlated with APACHE II score and inflammatory markers; and (3) lncRNA ITSN1‐2 was highly expressed in non‐survivors compared to survivors, and it could well distinguish survivors from non‐survivors in sepsis patients. Here, ITSN1 is linked to Sepsis.