ITSN1 and Sepsis: In the present study, we uncovered that the expression of circulating lncRNA ITSN1‐2 was elevated in sepsis patients compared to healthy controls and it presented good value on distinguishing sepsis patients from healthy controls with AUC 0.777, which might be caused by that lncRNA ITSN1‐2 was able to serve as a promoter in regulating expression of inflammation‐related proteins by activation of multiple inflammatory pathways, inducing systemic inflammatory response in sepsis patients; thereby, its expression was higher in sepsis patients.