PDCD1 and neoplasm: 2017, demonstrating that SATB1 recruits the nucleosome remodeling deacetylase complex to the regulatory regions of the Pdcd1 gene, encoding PD‐1, and thereby preventing its transcription early after CD8+ T‐cell activation.22 Furthermore, the addition of transforming growth factor β (TGF‐β), frequently found in the tumor environment, to human T‐cell cultures, resulted in impairment of TCR‐induced SATB1 expression and therefore concomitant increase of PD‐1 expression.