APOE and gastric cancer: EVs derived from neural stem cells have been shown to transfer IFN‐γ, activating the ISG pathway via Stat1 signalling in target cells.39 Microvesicles secreted by macrophages have also been shown to shuttle invasion‐potentiating microRNAs into breast cancer cells.40 TAMS‐derived miR‐21 has been shown to confer cisplatin resistance in gastric cancer cells,41 and TAMS‐derived exosomes are known to promote migration of gastric cancer cells by EV transfer of functional Apolipoprotein E.42 In respect to HCV infection, Cai et al43 have shown macrophage‐derived EVs induce long‐lasting immunity.