Consequently, many DNA viruses, such as herpes simplex 1 (HSV-1), human cytomegalovirus (HCMV), simian virus 40 (SV40) and adenovirus 5 (ADV5), target PML NBs during primary infection and induce the reorganization and degradation of the residing proteins, including PML protein and Sp100 [11–15]. The gene discussed is SP100; the disease is infection.