POU2AF1 and diffuse large B-cell lymphoma: When we analyzed the POU2AF1 gene in a group of 48 de novo DLBCL samples, including germinal center B-cell like (GCB) and non-GCB cases classified according to cell of origin, we found only one mutated case in the series (personal unpublished observations), suggesting that this alteration might be specific to DLBCL of transformed patients (Fisher’s exact test p = 0.001).