FGF21 and early-onset autosomal dominant Alzheimer disease: Furthermore, the contribution of metabolic disturbances in glucose homoeostasis and insulin insensitivity is well recognized in Alzheimer's’ disease, and FGF21 may have the utility to reverse that component of pathogenesis (Yarchoan and Arnold, 2014; Willette et al., 2015; Rodriguez-Rodriguez et al., 2017).