Similarly, Asadi et al. (2018) reported that administration of 7.5 μg/kg irisin directly into the brain (intracerebroventricular [ICV]) in MCAO-stroke-injured rats reduced neurological deficits, decreased infarct size, decreased brain edema, and decreased TUNEL staining and other markers of apoptosis. Here, FNDC5 is linked to stroke disorder.