Blocking RBM3 upregulation by RNAi prevented neuroprotective and cognitive improvements induced by hibernation-like cooling in transgenic mice afflicted with Alzheimer's disease (5XFAD) or inoculated with prions to induce severe neurodegeneration (tg37 mice) (Peretti et al., 2015). The gene discussed is RBM3; the disease is Alzheimer disease.