Blocking RBM3 upregulation by RNAi prevented neuroprotective and cognitive improvements induced by hibernation-like cooling in transgenic mice afflicted with Alzheimer's disease (5XFAD) or inoculated with prions to induce severe neurodegeneration (tg37 mice) (Peretti et al., 2015). This evidence concerns the gene RBM3 and early-onset autosomal dominant Alzheimer disease.