APP and Alzheimer disease: Multiple miRNAs are proved to be expressed abnormally in the CNS44, 45 and they have been implicated in a wide range of pathophysiological processes such as neurodegenerative disease.46, 47 For instance, miR‐34a is enriched in the cerebral cortex of AD mouse models and contributes to the pathogenesis of AD.48 Our previous study described that miR‐107 is down‐regulated in Abeta‐incubated ECs.