Mitogen‐activated protein kinase family which include ERK, p38, and c‐Jun NH2‐terminal kinase (JNK) modulate tumor progression through upregulation of downstream kinases and transcription factors.34 NF‐κB activation may be regulated by AKT or MAPKs cascades.11 We used NF‐κB reporter gene assay to evaluate effect of AKT or MAPK inhibitors on NF‐κB activation in TSGH 8301 cells. Here, AKT1 is linked to neoplasm.