H19 can promote the development of CRC via generating miRNA or by serving as ceRNA.12 Down‐regulation of lncRNA MEG3 can promote colorectal adenocarcinoma cell proliferation and inhibit the apoptosis by up‐regulating TGF‐β1 and its downstream sphingosine kinase 1.13 Koduru et al identified differentially expressed lncRNAs in CRC samples. This evidence concerns the gene SPHK1 and colorectal carcinoma.