piR59056, piR‐54878 and piR‐62701 are also highly expressed in CRC, and are associated with recurrence‐free survival.91 piR‐823 contributes to colorectal tumorgenesis by enhancing the transcriptional activity of HSF1.100 Chu et  al observed that an lncRNA, LNC00964‐3, which includes the piR‐015551 sequence, is significantly lower in CRC tissues. The gene discussed is HSF1; the disease is colorectal carcinoma.