Increased activation of endothelial cell NOX5 causes cell proliferation and formation of capillary‐like structures, important in atherosclerosis and angiogenesis (Guzik et al., 2008; Wang & Hartnett, 2017), and these processes are mediated via stromal cell‐derived factor‐1α and c‐Jun N‐terminal kinase 3 (Pi et al., 2014). The gene discussed is NOX5; the disease is atherosclerosis.