MPC1 and hereditary clear cell renal cell carcinoma: Recent reports have indicated that MPC1 often shows low expression in many carcinomas compared to normal cells and MPC2 tends to be highly expressed.6 It is also known that low MPC1 expression in colon cancer, renal cell carcinoma, and lung cancer has poor survival.6 In contrast, the effects of changes in the expression of the MPC subtype on the tumor are still poorly understood.