To determine whether such neutralization is dependent upon LAL-mediated degradation of the quasi-envelope within lysosomes, we pre-treated Huh-7.5 cells with Lalistat-2 prior to infection with naked HAV or eHAV, and added anti-HAV-positive human plasma (‘JC’ plasma) at intervals following removal of the inoculum. The gene discussed is LIPA; the disease is infection.