KLK3 and cancer: Many prostate tumors display a protracted disease trajectory, almost indolent in behavior.19 The widespread use of the serum PSA test in many countries has significantly increased the incidence and thus overtreatment of these low-risk cancers with little likelihood of clinical manifestation.20-23 An important first consideration in developing epiCaPture was to therefore critically appraise the evidence for prognostic utility of each constituent gene.