IGF1 and posterior cortical atrophy: Early studies demonstrated detection of GSTP1 methylation in urine from patients with PCa, although sensitivity was poor (less than 30%).39 Follow-up work expanded the repertoire of markers (GSTP1, APC, and RARβ2), which improved sensitivity to approximately 60%.40 The epiCaPture panel represents five commonly perturbed pathways in PCa: intracellular detoxification, Wnt and IGF axes, cell cycle, and prostaglandin biosynthesis.