For instance, Tmem100 expression is significantly downregulated in human hepatocellular carcinoma,45 NSCLC,26 and glioblastoma,67 whereas overexpression of Tmem100 in NSCLC cell lines inhibits tumor cell proliferation.21,26 Together, these studies suggest that Tmem100 may act as an important cell proliferation regulator. Here, TMEM100 is linked to hepatocellular carcinoma.