Furthermore, Calderero et al. have shown that PD-L1 expression by neoplastic cells and inflammatory cells in the tumor microenvironment (TME) of HCCs is significantly correlated with markers of tumor aggressiveness (13), and increased PD-L1 expression in HCC is associated with poor prognosis (6, 14) and disease recurrence (15). Here, CD274 is linked to hepatocellular carcinoma.