The expression of ATM serine/threonine kinase (ATM), Bloom syndrome, RecQ helicase like (BLM), Breast cancer 2, early onset (BRCA2), BRCA1 interacting protein C-terminal helicase 1(BRIP1), Nibrin (NBN), partner and localizer of BRCA2 (PALB2) was increased in tumors treated with Andrographolide 10 mg/kg. The gene discussed is PALB2; the disease is Down syndrome.