GPC1 and familial pancreatic carcinoma: The concept of a panel of EV biomarkers as opposed to one has already shown promise for diagnosis of pancreatic cancer such as Yang et al., in which five EV based biomarkers exhibited a significantly higher accuracy rate (94-100%) compared to GPC1 expressing EVs (56%) [37] might be more effective, especially given that a test with any false positive rate would generate concern when used across a large screening population.