MDM2 and cancer: Although LATS2 stabilizes p53 in human cancer cells by inhibiting MDM2 [68], it also might maintain stemness of SAS cells by inhibition of p53-dependent differentiation; SAS cells harbor a mutant p53 protein in which both the tetramerization domain and the C-terminal regulatory domain are deleted due to a truncation at E366 (http://p53.free.fr/Database/Cancer_cell_lines/p53_cell_lines.html).