Likewise, one of the possible mechanisms is emphasized in the research of Gourban et al. where high levels of VEGF, PDGF, and PF4 were marked as possible clarification of elevated platelet count in patients with CRC, assuming that platelets could provoke new vessel development, as well as prevent bleeding from new vessels, leading to tumor cell promotion [26]. The gene discussed is PF4; the disease is colorectal carcinoma.