Furthermore, tumor-infiltrating monocytic myeloid-derived suppressor cells (MO-MDSC) and granulocytic myeloid-derived suppressor cells (PMN-MDSC) from B16-bearing mice could produce higher levels of CCL3, CCL4, CCL5 than that in control mice at melanoma sites, especially MO-MDSCs (28). This evidence concerns the gene CCL5 and melanoma.