CCR2 and colon carcinoma: Although CCR2 is expressed in human endothelial cells, in the context of TEC, activation of CCR2 leads to phosphorylation of kinases JAK2 and p38MAPK and transcription factor Stat5, which enhances endothelial permeability and enables colon carcinoma extravasation and metastasis in preclinical mouse models (36).