In lung cancer, CXCR2 is expressed on the vascular endothelium in human non-small cell lung carcinomas and in experimental mouse lung cancer models [orthotopic syngeneic Lewis lung carcinoma (LLC) tumors], and elevated levels of CXCL1, CXCL2/3 were detected in tumor vs. matched normal tissue controls (77). This evidence concerns the gene CXCL1 and lung cancer.