A genetic deletion that includes the GRIA2 gene encoding GluA2 is associated with autism (Ramanathan et al., 2004) and mutations of RAB39B that cause intellectual disability comorbid with autism lead to impaired transport of GluA2 to synapses and subsequent shift of AMPAR to higher calcium permeability (Mignogna et al., 2015). Here, GRIA2 is linked to autism.