The subsequent study showed that low dose of 5-HT1A receptor agonist 8-OH-DPAT potentiated sub-threshold dose of resveratrol’s effects on IBS-like symptoms; while pretreatment with 5-HT1A antagonist NAN-190 prevented such effects, further supporting the involvement of 5-HT and the 5-HT1A receptor in the effects of resveratrol on IBS-like symptoms. The gene discussed is HTR1A; the disease is irritable bowel syndrome.