In order to determine whether the effects of resveratrol on depression- and anxiety-like behavior were related to 5-HT and its receptor’s function, the antidepressant- and anxiolytic-like effects of sub-threshold dose of resveratrol (10 mg/kg) combined with low dose of 5-HT1A receptor agonist 8-OH-DPAT (0.5 mg/kg) were investigated. This evidence concerns the gene HTR1A and depressive disorder.