Induction of proNGF and p75NTR has been observed in several injury models and neurodegenerative diseases (Harrington et al., 2004; Song et al., 2010; Alder et al., 2016) and the blockage of proNGF/p75NTR signaling is effective in limiting neuronal apoptosis (Fahnestock et al., 2001; Beattie et al., 2002; Harrington et al., 2004; Arnett et al., 2007; Jansen et al., 2007; Tep et al., 2013). This evidence concerns the gene NGFR and neurodegenerative disease.