Aβ accumulation may activate NMDARs at early stages of AD (Parameshwaran et al., 2008), and that Aβ oligomers can evoke an immediately [Ca2+]i rise through activation of GluN2B-containing NMDARs in cultured cortical neurons (Ferreira et al., 2012). Here, GRIN2B is linked to Alzheimer disease.