reported that HSV-1 was retargeted to a specific receptor IL13Rα2 expressed in malignant glioma, by ablating the HS-binding sites of gB and gC, and the insertion of IL-13 in the N-terminal of gC and gD, but the recombinant virus can still infect normal cells by interaction with HVEM or nectin 1 (Zhou et al., 2002). Here, GC is linked to malignant glioma.