LDLR and neoplasm: We herein developed LDL modified lipidic silica nanoparticles (LDL-SLN) as a preferable DDS for the co-delivery of Sor and Dox, with the aim to construct a DDS (LDL-SLN/Sor/Dox) that able to deliver two drugs (Sor and Dox) specifically to the tumor site via LDLR mediated tumor-homing property, which was expected to achieve enhanced antitumor effect compared to unmodified SLNs and single drug.