We identified motifs associated with the EGR family of TFs in EC1 (late responsive IL-4 clusters) and the Microphthalmia-associated (MAF) TF family in EC2 and EC3 (early and intermediate responsive IL-4 clusters), as proposed by recent studies (42,43), as well as MITF and RUNX under the IL-4 specific ECs. The gene discussed is MITF; the disease is microphthalmia.