The AS01B and AS02A adjuvants both contain TLR4 agonist MPL and the saponin QS-21, but AS01B is a liposome-based adjuvant whereas AS02A is an oil-in-water emulsion [26]; RTS,S administered with either adjuvant appears to induce similar IgG subclass profiles in malaria-exposed children. Here, TLR4 is linked to malaria.