However, RAP1 deficiency decreased the proliferation of the human hepatocellular carcinoma cell line HepG2 and non-small cell lung cancer cell line A549 (Zha et al., 2014; Xiao et al., 2017), but not that of the human fibrosarcoma cell line HT1080 (Kabir et al., 2014) or mouse MSCs (Ding et al., 2018). This evidence concerns the gene TERF2IP and hepatocellular carcinoma.