We further tested the function of METTL3-m6A-CDCP1 axis in bladder cancer initiation and found that forced expression of METTL3 or CDCP1 functionally interplay with Cd to promote the bladder cancer tumorigenesis, supporting the synergistic effect of METTL3-m6A-CDCP1 axis and chemical carcinogens in promoting oncogenic transformation. The gene discussed is METTL3; the disease is urinary bladder carcinoma.