However, whereas STING was indispensable to the induction of IFNβ in response to cytosolic DNA, it was not involved in responses to cytosolic RNA, as shown by the direct delivery of RNA into the cytosol.1,2 Although activation of the cGAS-STING pathway has been implicated during infection by RNA viruses, such as with the Dengue virus,54,55 the importance of STING in the resistance to RNA viruses remains unclear. The gene discussed is CGAS; the disease is infection.