STING1 and cancer: Modulation of the cGAS-STING pathway has attracted attention in recent years with the discovery of cGAS inhibitors44,45 in addition to several STING agonists that are used in cancer therapy.46,47 Despite the currently limited understanding of how STING hyperactivation leads to inflammation, it remains highly desirable to identify compounds that can directly target and inhibit STING signaling.