A full decade has passed since STING was first described as an important innate signaling molecule.1,50,51 STING was identified as a strong inducer of type I IFNs through the activation of TANK-binding kinase 1 (TBK1) and, subsequently, of the transcription factor IFN regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB).1,2,52,53 Interestingly, STING was demonstrated to be important for resistance to infection by both RNA and DNA viruses. The gene discussed is STING1; the disease is infection.