In this study, 73 OV marker genes were discovered to have emerged in the origin of the first cell (PS1 and PS2), including CCNE1-amplified high-grade serous ovarian cancer (HGSC) dependent kinase CDK287 and the oncogenic capacity of advanced-stage ovarian cancer enhancing protein PRKAB188. This evidence concerns the gene CCNE1 and ovarian serous adenocarcinoma.