MTHFR and age-related macular degeneration: The current study pointed out that the thrombophilic MTHFR-C677T polymorphism, already recognized as positive predictor in short-term angiographic response to PDT-V of AMD-related C- and PC-CNVs57, get better the long-term outcomes of standardized, pro-re-nata, PDT-V protocol among patients with neovascular AMD.