MTHFR and age-related macular degeneration: Although the common 677 C > T polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR-C677T; rs1801133) has been described as positive pro-thrombotic factor for the closing of C- and PC-CNVs secondary to AMD after a single PDT-V procedure57, its role in determining the long-term outcomes of photodynamic protocol has not yet been evaluated.