PREX2 and hepatocellular carcinoma: Additionally, 11.8% (8/68) of HCC samples had a 1-nucleotide deletion as a frameshift mutation (K400fs) of PREX2 which resulted in a truncated form of PREX2 protein containing only the N-terminal Dbl-homologous-Pleckstrin-homology (DH-PH) tandem domain.