For example, both P948S and G844D mutants were from melanoma and located in the IP4P domain; the interaction between PREX2 P948S and C2-tail or full-length PTEN was in a way similar to that of wild-type PREX2, but PREX2 G844D interacted with C2-tail or full-length PTEN in a much weaker degree12. This evidence concerns the gene PTEN and melanoma.