AKT1 and hepatocellular carcinoma: Several signal transduction pathways involved in HCC were identified including the Ras/Raf/MEK/ERK pathway, pro-angiogenic pathways, EGFR pathway, PI3K/AKT/mTOR pathway, HGF/c-Met pathway, IGF/IGFR system, and histone deacetylase inhibitors8.