There have been a few studies about Apoe knockout rats as atherosclerosis model generated via TALEN26 or CRISPR/Cas928, indicating that Apoe knockout rat is more resistant to hyperlipidemia-induced endothelial injury than mouse; however, it is also indicated that if fed with HFD for longer period of time and given the atherogenic event, such as ligation of artery, Apoe knockout rats would develop atherosclerosis. This evidence concerns the gene APOE and hyperlipidemia.