It is interesting to note that repair-like patrolling macrophages (CD11b + Ly6C−F4/80 +), we here identify as associated with CI-deficient cancers, have been described to promote angiogenesis and fibrosis in the wound47, meaning that their abundance in the context of cancer might explain the fibroblast contribution we observe in CI-deficient tumors. This evidence concerns the gene ITGAM and cancer.