Subsequently, to investigate the phenotypic consequences of CI disruption in cells undergoing neoplastic transformation in an otherwise wild-type organ, mimicking mammalian cancer onset, we induced ndufv1 knockdown in a cooperative system, extensively used to recapitulate clonal carcinogenesis in Drosophila, where a lgl loss of function mutation is combined with oncogenic Ras (RasV12)23. Here, NDUFV1 is linked to cancer.