Additionally, the treatment of CI-competent xenografts with metformin, besides reducing tumor growth at comparable levels with genetic CI KO (Supplementary Fig. 15c), led to a higher number of intra-tumor macrophages than their untreated controls, as well as to a higher number of CD11b + F4/80 + Ly6C− cells (Supplementary Fig. 15d, e). This evidence concerns the gene ITGAM and neoplasm.