Yu and coworkers28 found that the transcriptional level of LMO4 is higher in invasive pancreatic ductal carcinoma than in normal pancreatic ductal cells and some other types of pancreatic cancer; meanwhile, Murphy and colleagues29 also found that the prognosis of pancreatic cancer with low LMO4 expression is poor, indicating that LMO4 plays a complex role in the development of pancreatic cancer. The gene discussed is LMO4; the disease is pancreatic neoplasm.