ITPR1 and nonpapillary renal cell carcinoma: In these tumors, we observed decreased or unchanged expression of the IP3R1 in tumors compared to unaffected part of kidney (Fig. 1a), while gene expression of the IP3R2 was mostly downregulated (Fig. 1b) and the expression of the IP3R3 was predominantly upregulated (Fig. 1c) in ccRCC compared to corresponding unaffected tissue.