Among the suggestive associations, 3 are linked to genes with experimental evidence of influence on outcome from animal models of stroke and are discussed below.19, –, 21 First, rs2236406, an intron variant in the PTCH1 gene, was identified in the mRS 0–2 vs 3–6 analysis (table 2, figures 3) and 4). This evidence concerns the gene PTCH1 and stroke disorder.