NaV1.7 KO iPSC nociceptors recapitulated the excitability changes observed in CIP lines, including an increased rheobase (HC1 101.6 ± 5.3 pA versus NaV1.7 KO 145.5 ± 9.7 pA, p < 0.001) (Figures 6A and S6A) and a decreased propensity to fire repetitively to supra-threshold stimulation (Figures 6B and S6B). This evidence concerns the gene SCN9A and hereditary sensory and autonomic neuropathy.