Consistent with studies of rodent NaV1.7 KO DRGs (Raouf et al., 2012), we observed reliable hypoexcitability in CIP iPSC nociceptors, demonstrable by an increased current threshold to activation and a reduction in action potential firing in response to prolonged supra-threshold stimulation. This evidence concerns the gene SCN9A and hereditary sensory and autonomic neuropathy.