HTRA1 and age-related macular degeneration: The high expression of HTRA1 GG genotype was also reported by Yang et al. [10] and DeWan et al. [9] in a study between AMD and healthy controls whereby the AMD subjects had a higher expression of HTRA1. The overexpression of HTRA1 has been related to the alteration of Bruch’s membrane, resulting in the invasion of the extracellular matrix with choroid capillaries and inhibition of the angiogenesis and extracellular matrix deposition regulator (TGF-β) [10].