AFP and neoplasm: As shown in Table 2, low expression of circSETD3 in HCC tissues was significantly correlated with larger tumour size (P = 0.01) and poorer tumour differentiation (P = 0.01), but not with other characteristics of HCC that included the level of alpha fetoprotein level, tumour number, Barcelona Clinic Liver Cancer (BCLC) stage, vascular invasion and other features.