As shown in Table 2, low expression of circSETD3 in HCC tissues was significantly correlated with larger tumour size (P = 0.01) and poorer tumour differentiation (P = 0.01), but not with other characteristics of HCC that included the level of alpha fetoprotein level, tumour number, Barcelona Clinic Liver Cancer (BCLC) stage, vascular invasion and other features. The gene discussed is AFP; the disease is hepatocellular carcinoma.