Support for the use of combined biomarkers to improve their predictability value came from a study in adult patients who underwent CPB surgery, where using urinary biomarkers KIM-1, NAG, and NGAL predicted AKI 3 h from the operation by 0.65 for KIM-1; 0.63 for NAG; and 0.65 for NGAL [59]. The gene discussed is HAVCR1; the disease is acute kidney injury.