NPM1 and acute myeloid leukemia: Herein, 11 genetic subgroups of AML have been proposed, including AML with: inv(16), t(15;17), t(8;21), MLL fusion, inv(3), t(6;9), NPM1, CEBPA, TP53 aneuploidy, chromatin spliceosome and IDH2 mutations [1].