They found that mutations in epigenetic regulators (ASXL1, EZH2) and the cohesin complex were more common in AML-patients bearing t(8;21), whereas they were nearly absent in AML patients with inv(16) (42% vs. 6% for mutatiotions in epigenetic regulators, p < 0.001; 18% vs. 0% for cohesion complex mutations, p < 0.001) [39]. Here, EZH2 is linked to acute myeloid leukemia.