Similarly, in a cohort of 97 patients with AML (treated with intensive chemotherapy and allogeneic transplantation) and a high risk cytogenetic profile (defined as either complex karyotype, monosomy of chromosome 7, monosomy and/or deletion of the long arm of chromosome 5 and abnormalities of chromosome 17p), the presence of a TP53 mutation at diagnosis was associated with inferior outcomes after allogeneic transplantation with a three-year survival rate of 33% in patients without TP53 mutation and 10% in patients with mutated TP53 (p = 0.002) [51]. This evidence concerns the gene TP53 and acute myeloid leukemia.