The 2017 update now divides AML into three (instead of four) risk groups (i.e., favorable, intermediate and adverse), based on the results of conventional cytogenetics and single gene mutations in NPM 1, FLT3, biallelic CEBPA, RUNX, ASXL1 and TP53 [24]. This evidence concerns the gene FLT3 and acute myeloid leukemia.