FOXM1 and cancer: Herein, we: 1) investigated changes in and links between FOXM1 copy number, mRNA, and protein expression across TCGA cancers; 2) compared FOXM1 expression in cancer vs. normal tissues; 3) identified key genomic features that contribute to increased FOXM1 expression using both pan-cancer analyses and engineered cell models; and 4) determined the association between FOXM1 expression and cancer genomic instability.