Sartrolide H (94) and 4Z,12Z,14E-sarcophytolide (98) had moderate inhibitory activity against protein tyrosine phosphatase 1B (key target for the treatment of type-II diabetes and obesity) with IC50 = 19.9 and 15.4 μM, respectively, significantly less than the positive control, oleanolic acid (IC50 = 2.6 μM). The gene discussed is PTPN1; the disease is obesity due to melanocortin 4 receptor deficiency.