Regarding TORKIs, our group has recently documented that Torin-2, displayed cytotoxicity to a panel of Ph− B-ALL cell lines and it was found that the drug as a single agent was able to suppress feedback activation of PI3K/Akt, whereas RAD001 needed the addition of MK-2206 to show the same effect [142]. The gene discussed is PIK3CD; the disease is acute lymphoblastic leukemia.